By Robert Lev
Adenomatous Polyps of the Colon: Pathobiological and Clinical Features consolidates the gigantic physique of simple technological know-how and medical facts linked to adenomatous polyps of the colon, a lot of it encouraged via the conclusion that the majority colorectal carcinomas appear to come up in such polyps. This ebook strives to judge those information, with specific emphasis on their implications for administration of polyp-bearing topics. subject matters comprehensively explored comprise anatomy and histology of the traditional colon; pathologic features of adenomatous polyps, differential analysis, and grading schemes for measure of dysplasia and villosity; adenomatous polyposes; histologic and epidemiologic facts for the malignant capability of adenomatous polyps; and detection and administration, with certain consciousness to endoscopy, endoscopic polypectomy, the malignant polyp, and post-polypectomy surveillance schedules.
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Additional resources for Adenomatous Polyps of the Colon: Pathobiological and Clinical Features
In B Morson (ed): Current Topics in Pathology: Vul 63. Pathology of the Gastrointestinal Tract. Springer-Verlag, Berlin, pp 95-141. Enterline HT, Arvan DA (1967) Chromosome constitution of adenoma and adenocarcinoma of the colon. Cancer 20:1746-1759. Estrada R, Spjut H (1980) Hyperplastic polyps of the large bowel. Am J Surg Pathol 4:127-133. Fearon ER, Hamilton SR, Vogelstein B (1987) Clonal analysis of human colorectal tumors. Science 238:193-197. Feczko PJ, Bernstein MA, Halpert RD, Ackerman LV (1984) Small colonic polyps: A reappraisal of their significance.
Knoernschild HE (1963) Growth rate and malignant potential of colonic polyps: Early results. Surg Forum 14:137-138. Kokal W, Sheibani K, Terz J (1986) Tumor DNA content in the prognosis of colorectal carcinoma. JAMA 255:3123-3127. Konishi F, Morson B (1982) Pathology of colorectal adenomas: A colonoscopic survey. J Clin Pathol 35:830-841. Kozuka S (1975) Premalignancy of the mucosal polyp in the large intestine. I. Histologic gradation of the polyp on the basis of epithelial pseudostratification and glandular branching.
5 cm in size, grew very slowly or not at all during the two- to nine-year follow-up period. There are very few data on the exact doubling times of polyps that are subsequently determined histologically to be benign, however. , 1984). 3 summarizes a recent review by Spratt and Spratt (1985) that shows doubling times from four earlier studies, including the Welin work cited above. 3. Mean doubling times for adenomatous polyps, carcinomas, and metastases. Polyps Carcinomas Metastases n Arithmetic mean (days) Range (days) 77 1,600 668 221 13-8,664 52-10,000 98 23 32-3,300 SOURCE: Modified from Spratt and Spratt, 1985.
Adenomatous Polyps of the Colon: Pathobiological and Clinical Features by Robert Lev