By P.B. Bradley
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Extra info for Anticholinergic Drugs and Brain Functions in Animals and Man
G. (1963) Electroencephalographic and behavioral analysis of drug effects on an instrumental reward discrimination in rabbits. Psychophurmacofogia, 4, 126-1 38. 36 MEHES,J. (1929) Studien iiber den Skopolaminschlaf und seine Verstarkung durch Morphium. Arch. exp. Path. , 142, 309-322. 37 NICKANDER, R. C. AND YIM,G. K. W. (1964) Effects of tremorine and cholinergic drugs on the isolated cerebral cortex. Int. J. , 3, 571-578. 38 OSTFELD, A. M. AND ARUGUETE, A. (1962) Central nervous system effects of hyoscine in man.
Other differences between central and peripheral actions among the anticholinergic compounds are shown in Table I. The very low amplitude (4 to 33 p V ) EEG tracing obtained from the midbrain of these animals was not significantly changed by any of the anticholinergic drugs or by electrostimulation (Fig. 2). Even anesthetic doses of pentobarbital (25 mg/kg) when administered slowly did not increase the amplitude. These findings are in contrast to those obtained in intact rabbits where a midbrain EEG pattern is seen which closely resembles the electrocorticogram in magnitude and in response to these drugs and to electrical stimulation53.
8, 151-173. 28 JENKNER, F. L. , A. (1953) Bulbar reticular formation and tremor. Arch. Neirrol. Psychiat. (Chicago), 70,489-502. 29 KRUSE,W. (1960) Treatment of drug-induced extrapyramidal symptoms. Dis. New. , MAGNI,F. AND ROW,G. F. (1960) Electrophysiological analysis of the action of atropine on the central nervous system. Arch. ital. , 98, 293-307. 31 LONGO,V. G. (1956) Effects of scopolamine and atropine on electroencephalographic and behavioral reactions due to hypothalamic stimulation.
Anticholinergic Drugs and Brain Functions in Animals and Man by P.B. Bradley