By Paul J. Thuluvath
As there's a excessive occurrence of disorder recurrence after liver transplantation, this quantity is designed round the want for a reference textual content dealing completely with this challenge. The e-book locations distinctive emphasis on pre- and post-transplant predictors of recurrence, severity overview, prophylaxis, and remedy. Pathobiology of affliction recurrence is mentioned intimately the place appropriate. matters together with caliber of existence and price burden also are coated within the text.
Written by way of famous specialists in each one box, Disease Recurrence After Liver Transplantation: traditional background, remedy and Survival serves as a complete reference for physicians and surgeons who look after liver transplant recipients and an incredible addition to the literature detailing the present figuring out of disorder recurrence.
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Extra info for Disease Recurrence After Liver Transplantation: Natural History, Treatment and Survival
1991;13(1):90–6. 51. Hwang S, Ahn CS, Song GW, et al. Posttransplantation prophylaxis with primary high-dose hepatitis B immunoglobulin monotherapy and complementary preemptive antiviral add-on. Liver Transpl. 2011;17(4):456–65. 52. Dickson RC, Terrault NA, Ishitani M, et al. Protective antibody levels and dose requirements for IV 5% Nabi Hepatitis B immune globulin combined with lamivudine in liver transplantation for hepatitis B-induced end stage liver disease. Liver Transpl. 2006;12(1):124–33.
Recently, Gane et al. reported the results of a combination prophylaxis using LAM and ADV without HBIG in 18 patients who had documented suppression of HBV DNA below 3 log10 IU/mL before LT . No case of HBV recurrence was observed after a median follow-up of 22 months. The combination of LAM and ADV is cost-effective as compared to low-dose IM HBIG and LAM. The availability of more potent antivirals with a higher barrier to resistance could increase the proportion of patients with undetectable HBV DNA pre-transplantation and decrease the risk of recurrent disease post-transplantation .
Am J Transplant. 2010;10(8):1861–9. 56. Han SH, Ofman J, Holt C, et al. An efﬁcacy and cost-effectiveness analysis of combination hepatitis B immune globulin and lamivudine to prevent recurrent hepatitis B after orthotopic liver transplantation compared with hepatitis B immune globulin monotherapy. Liver Transpl. 2000;6(6):741–8. 57. Markowitz JS, Martin P, Conrad AJ, et al. Prophylaxis against hepatitis B recurrence following liver transplantation using combination lamivudine and hepatitis B immune globulin.
Disease Recurrence After Liver Transplantation: Natural History, Treatment and Survival by Paul J. Thuluvath